发明名称 |
TRITERPENOIDS WITH HIV MATURATION INHIBITORY ACTIVITY, SUBSTITUTED IN POSITION 3 BY A NON-AROMATIC RING CARRYING A HALOALKYL SUBSTITUENT |
摘要 |
Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, triterpenoids that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formula I: with X selected from C4-8 cycloalkyl, C4-8 cycloalkenyl, C4-9 spirocycloalkyl, C4-9 spirocycloalkenyl, C4-8 oxacycloalkyl, C4-8 dioxacycloalkyl, C6-8 oxacycloalkenyl, C6-8 dioxacycloalkenyl, C6 cyclodialkenyl, C6 oxacyclodialkenyl, C6-9 oxaspirocycloalkyl and C6-9 oxaspirocycloalkenyl ring, such that X is substituted with A, wherein A is -C1-6 alkyl- halo. These compounds are useful for the treatment of HIV and AIDS. |
申请公布号 |
PH12016501951(A1) |
申请公布日期 |
2017.01.09 |
申请号 |
PH12016501951 |
申请日期 |
2016.10.03 |
申请人 |
VIIV HEALTCARE UK (NO. 4) LIMITED |
发明人 |
SIT, SING-YUEN;CHEN, YAN;CHEN, JIE;SWIDORSKI, JACOB;VENABLES, BRIAN LEE;SIN, NY;MEANWELL, NICHOLAS A.;REGUEIRO-REN, ALICIA;HARTZ, RICHARD A.;XU, LI;LIU, ZHENG |
分类号 |
A61K31/56;A61K31/58;A61P31/18;C07C309/65;C07F5/02;C07J63/00 |
主分类号 |
A61K31/56 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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