| 摘要 |
Disclosed are substituted phenyl-3-aza-bicyclo[3.1.0]hex-3-yl-methanones of general formula (I)wherein R, R, R, R, Rand Rare as described herein and salts thereof, preferably pharmaceutically acceptable salts thereof. Further disclosed are the manufacture of said compounds, pharmaceutical compositions comprising compounds according to general formula (I), and the use of said compounds for the treatment of various pathological conditions such as conditions concerning positive and negative symptoms of schizophrenia as well as cognitive impairments associated with schizophrenia, Alzheimer's Disease and other neurological and psychiatric disorders. The compounds of the invention show glycine transporter-1 (GlyT1) inhibiting properties. |
