タウタンパク質の多重突然変異体およびヒトタウオパチーを再現するためのその使用

摘要

The present invention relates to a tau protein comprising at least four different mutations selected from group consisting of mutations which cause the condition frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17), and to nucleic acids encoding said tau protein. The invention further pertains to methods for identifying an agent for treating or preventing neurogenerative disease, and to methods for recapitulating tauopathies.