发明名称 |
PROCESSES FOR PREPARING OPTICALLY ACTIVE DIAMINE DERIVATIVES |
摘要 |
The problem to be solved is to provide a method for efficiently producing compounds (1) and (1a) that are important intermediate compounds in the production of FXa inhibitors (X) and (X-a). The solutions thereto are a method for producing a compound represented by the formula (8d) using a stereoselective intramolecular cyclization reaction, and a method for producing a compound (If) or a salt thereof, or a hydrate thereof, which is characterized by desulfonylation of the compound (8d). In each formula, R 4a represents a C1-C6 alkyl group, a benzyl group, etc. |
申请公布号 |
EP2980067(A4) |
申请公布日期 |
2016.10.26 |
申请号 |
EP20140774515 |
申请日期 |
2014.03.28 |
申请人 |
DAIICHI SANKYO COMPANY, LIMITED |
发明人 |
NAKAMURA, YOSHITAKA;MICHIDA, MAKOTO;KANEDA, TAKESHI |
分类号 |
C07C269/00;A61K31/444;A61P7/02;A61P43/00;C07B53/00;C07C271/24;C07C303/28;C07C303/34;C07C307/08;C07C309/66;C07C309/73;C07D285/14;C07D513/04 |
主分类号 |
C07C269/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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