发明名称 MODIFIED LECITHIN-CHOLESTEROL ACYLTRANSFERASE ENZYMES
摘要 PROBLEM TO BE SOLVED: To provide compounds, pharmaceutical compositions and methods for treating atherosclerosis, coronary heart disease, thrombosis, and for decreasing or prevention of accumulation of cholesterol in a subject.SOLUTION: The present invention provides modified LCAT proteins comprising an amino acid substitution in a wild type LCAT protein amino acid sequence.SELECTED DRAWING: None
申请公布号 JP2016182136(A) 申请公布日期 2016.10.20
申请号 JP20160124506 申请日期 2016.06.23
申请人 AMGEN 发明人 ZHOU MINGYUE;THOMAS BOONE;MEININGER DAVID PARK;MARGRIT SCHWARTZ;SHAN BEI;SHEN WENYAN
分类号 C12N9/10;A61K38/45;A61K39/395;A61K47/34;A61P3/00;A61P3/06;A61P7/02;A61P9/00;A61P9/10;A61P9/12;A61P25/28;A61P27/02;A61P29/00;C12N15/00;C12N15/09 主分类号 C12N9/10
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