发明名称 |
IMIDAZOLE DERIVATIVES AS IDO INHIBITORS |
摘要 |
Presently provided are IDO inhibitors of general formulae (VII), (VIII) as shown below and pharmaceutical compositions thereof, useful for modulating an activity of indoleamine 2,3-dioxygenase; treating indoleamine 2,3-dioxygenase (IDO) mediated immunosuppression; treating a medical conditions that benefit from the inhibition of enzymatic activity of indoleamine-2,3-dioxygenase; enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent; treating tumor-specific immunosuppression associated with cancer; and treating immunosupression associated with an infectious disease. |
申请公布号 |
EP2493862(B1) |
申请公布日期 |
2016.10.05 |
申请号 |
EP20100779364 |
申请日期 |
2010.10.27 |
申请人 |
NEWLINK GENETICS CORPORATION |
发明人 |
MAUTINO, MARIO, R.;KUMAR, SANJEEV;JAIPURI, FIROZ;WALDO, JESSE;KESHARWANI, TANAY;ZHANG, XIAOXIA |
分类号 |
C07D233/64;A61K31/4164;A61K31/4178;A61P31/00;A61P35/00;A61P37/00;C07D401/12;C07D403/12;C07D407/12;C07D409/12;C07D413/12;C07D417/12 |
主分类号 |
C07D233/64 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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