发明名称 |
2-ARYLBENZOFURAN-7-FORMAMIDE COMPOUNDS, PREPARATION METHOD AND USE THEREOF |
摘要 |
Provided in the present invention are a 2-arylbenzofuran-7-formamide compound as shown in general formula I or a pharmacologically or physiologically acceptable salt thereof, a preparation method thereof and use thereof in preparing anti-tumour drugs, wherein R 1 and R 2 are each independently hydrogen, straight or branched chained C 1 -C 4 alkyl, C 3 -C 4 cycloalkyl or saturated 5- or 6-membered heterocyclyl containing oxygen or nitrogen; or R 1 and R 2 together with N form an unsubstituted or substituted saturated 5- or 6-membered heterocyclyl containing at least one heteroatom, wherein the heteroatom is O, N and S, the substituent is a methyl on N; R 3 is a hydrogen atom or a chlorine atom; R 4 is a hydrogen atom or a fluorine atom; X is CH, CF or N; and Y is CH, CF or N. |
申请公布号 |
EP2813495(B1) |
申请公布日期 |
2016.09.28 |
申请号 |
EP20130746724 |
申请日期 |
2013.01.14 |
申请人 |
SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES;CISEN PHARMACEUTICAL CO., LTD. |
发明人 |
YANG, CHUNHAO;MIAO, ZEHONG;DING, JIAN;WANG, MENG;HE, JINXUE;TAN, CUN;CHEN, YI |
分类号 |
C07D307/81;A61P29/00;A61P35/00;C07D405/04;C07D405/12 |
主分类号 |
C07D307/81 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|