发明名称 |
TANDEM PURIFICATION OF PROTEINS |
摘要 |
The present disclosure provides methods for purifying products from a fluid. In some embodiments, provided purification methods use a combination of purification modes (e.g., protein A and ion exchange) operated in tandem, wherein at least one of the modes utilizes weak partitioning. In some embodiments, provided purification methods operate under robust conditions in which a degree of binding between a product and resin is maintained despite variations in operating parameters. |
申请公布号 |
EP2598515(B1) |
申请公布日期 |
2016.09.21 |
申请号 |
EP20110752642 |
申请日期 |
2011.07.29 |
申请人 |
PFIZER INC. |
发明人 |
COFFMAN, JONATHAN, LEE;GODAVARTI, RANGANATHAN;SHAMASHKIN, MICHAEL |
分类号 |
C07K1/18;C07K1/22;C07K1/36 |
主分类号 |
C07K1/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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