发明名称 |
GENETICALLY ENCODED FLUORESCENT SENSORS FOR DETECTING LIGAND BIAS AND INTRACELLULAR SIGNALING THROUGH cAMP PATHWAYS |
摘要 |
Described herein are novel fluorescent sensors for cyclic adenosine monophosphate (cAMP) that are based on single fluorescent proteins. These sensors use less visible spectrum than FRET-based sensors, produce robust changes in fluorescence, and can be combined with one another, or with other sensors, in a multiplex assay on standard fluorescent plate readers or live cell imaging systems. |
申请公布号 |
EP3065754(A2) |
申请公布日期 |
2016.09.14 |
申请号 |
EP20140858784 |
申请日期 |
2014.11.04 |
申请人 |
MONTANA MOLECULAR LLC |
发明人 |
HUGHES, Thomas, E.;TEWSON, Paul, H.;QUINN, Anne, Marie |
分类号 |
A61K38/00;C07K16/00 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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