RATIONALLY DESIGNED SYNTHETIC ANTIBODY LIBRARIES AND USES THEREOF

摘要

PROBLEM TO BE SOLVED: To provide a rationally designed synthetic antibody libraries and uses thereof.SOLUTION: There is provided a procedure to overcome the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity. The libraries are designed to reflect the preimmune repertoire naturally created by the human immune system and are based on rational design informed by examination of publicly available databases of human antibody sequences.SELECTED DRAWING: Figure 23