发明名称 |
FCYRIIB-SPECIFIC FC REGION VARIANT |
摘要 |
An objective of the present invention is to provide an Fc region variant with enhanced Fc³RIIb-binding activity, and/or enhanced binding selectivity to Fc³RIIb compared to Fc³RIIa (type R), as compared to those of a polypeptide containing an Fc region to which an amino acid alteration(s) has not been introduced; a polypeptide which includes the Fc region variant; a pharmaceutical composition containing the polypeptide; preventing therapeutic or preventive agent for immunological inflammatory diseases that includes the pharmaceutical composition; a production method thereof; and a method of enhancing Fc³RIIb-binding activity and also enhancing binding selectivity to Fc³RIIb compared to Fc³RIIa (type R). It was found that a polypeptide containing an antibody Fc region variant that contains an amino acid sequence in which an amino-acid alteration at position 238 (EU numbering) is combined with other specific amino-acid alterations enhances Fc³RIIb-binding activity, and/or enhances binding selectivity to Fc³RIIb compared to Fc³RIIa (type R). |
申请公布号 |
EP2889377(A4) |
申请公布日期 |
2016.08.03 |
申请号 |
EP20130831250 |
申请日期 |
2013.08.23 |
申请人 |
CHUGAI SEIYAKU KABUSHIKI KAISHA |
发明人 |
KATADA, HITOSHI;KADONO, SHOJIRO;MIMOTO, FUTA;IGAWA, TOMOYUKI |
分类号 |
A61K39/00;C07K16/00;C07K16/28;C07K16/30 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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