Aeration and agitation system for the culture of microorganisms in single use bioreactors

摘要

The present invention describes a device for improving the oxygen transfer in single use bioreactors thanks to an agitation-aeration system generating microbubbles with pore sizes ranging from 0,5 microns up to 1 mm. The microbubble generating system might be coupled to the agitation shaft, be independent of it or a combination of both simultaneously. This invention opens the door to the use of 2-2000 liters single use plastic bioreactors for the culture of different biological specimens (bacteria, yeasts, fungi, animal and plant cells) using a single type of bioreactor.