| 发明名称 |
LINCRNA-DEFICIENT NON-HUMAN ANIMALS |
| 摘要 |
Genetically modified non-human animals are provided that exhibit a functional lack of one or more lncRNAs. Methods and compositions for disrupting, deleting, and/or replacing lncRNA-encoding sequences are provided. Genetically modified mice that age prematurely are provided. Also provided are cells, tissues and embryos that are genetically modified to comprise a loss-of-function of one or more lncRNAs. |
| 申请公布号 |
EP3030653(A2) |
申请公布日期 |
2016.06.15 |
| 申请号 |
EP20140834544 |
申请日期 |
2014.08.07 |
| 申请人 |
REGENERON PHARMACEUTICALS, INC.;PRESIDENT AND FELLOWS OF HARVARD COLLEGE |
发明人 |
LAI, KA-MAN VENUS;GONG, GUOCHUN;RINN, JOHN;FRENDEWEY, DAVID;VALENZUELA, DAVID M. |
| 分类号 |
C12N15/00;A01K67/027;A61K48/00;C12N15/87 |
主分类号 |
C12N15/00 |
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