ARTIFICIAL ANTIBODY PRODUCED USING PARTIAL SEQUENCE OF ENOLASE PROTEIN ORIGINATED FROM PLASMODIUM FALCIPARUM, AND METHOD FOR PRODUCING SAME

摘要

Provided is a physiologically active peptide which comprises a partial amino acid sequence of enolase originated from Plasmodium falciparum and which has a molecular structure that meets the standards set for the production of GMP. A peptide having such a structure that two peptide molecules each comprising (i) an amino acid sequence A01-Ala-Ser-Glu-Phe-Tyr-Asn-Ser-Glu-Asn-Lys-Thr-Tyr-Asp-Leu-Asp-Phe-Lys-Thr-Pro-Asn-Asn-Asp-A02 (SEQ ID NO: 1) or (ii) an amino acid sequence A03-Ala-Ser-Glu-Phe-Tyr-Asn-Ser-Glu-Asn-Lys-Thr-Tyr-Asp-Leu-Asp-Phe-Lys-Thr-Pro-Asn-Asn-Asp-Lys-Ser-Leu-Val-Lys-Thr-A04 (SEQ ID NO: 2) are lined to a liker peptide represented by (iii) Lys-A05-Cys-A06 in such a manner that the two peptide molecules can be arranged in a biantennary form through amide bonds between carboxyl terminal of the two peptide molecules and two amino groups in a Lys residue in the linker peptide. Preferably, the peptide has a dimerized structure, in which the peptides are dimerized through an S-S bond formed between a Cys residue in the sequence for the linker peptide in one of the peptides and a Cys residue in the sequence for the linker peptide in the other of the peptides. (In the amino acid sequences (i), (ii) and (iii), each of A01 to A06 represents a molecule composed of an arbitrary number, including 0, of amino acid residues.)