Method and system for synthesizing nanocarrier based long acting drug delivery system for methadone

摘要

The embodiments herein provide a nano-carrier system for delivering a long-acting injectable drug of methadone and a method of synthesizing the same. The methadone entrapped nanoparticles are prepared using a lipid/phospholipid core which is coated by a polymer. The lipid and phospholipid are dissolved in organic solvent. This solution is transferred into an aqueous phase consisting of distilled water or a buffer. A solution of polymer is added drop wise. The drug entrapped nanoparticle formation is achieved by diffusion of the organic solvent within the aqueous solvent to obtain the nanoparticles. The drug gets entrapped within the nanoparticles via the anti-solvency effect of the aqueous matrix. The resulting drug nanocarriers are capable of releasing the drug in a slow rate upon injection. The synthesized drug carrying nanoparticles are cryopreserved stored for future administration. For better storage, the nanodispersion is dried to form a powder.

主权项

1. A system for slow and controlled release of a methadone which comprises nanoparticles comprising
an aqueous core which is made of water or a buffer; monostearyl glycerol; a phospholipid bilayer comprising methadone; and a chitosan coating forming an outermost layer, wherein the nanoparticle has a positive surface charge.