Method to predict or diagnose a gastointestinal disorder or disease

摘要

The disclosure provides methods and compositions useful for identifying a subject's predisposition to a gastrointestinal disease or disorder.

主权项

1. A method for determining if a human subject has an increased risk of having colorectal cancer comprising:
collecting a buccal swab sample of mucosal cells from the subject; generating cDNA from RNA isolated from the buccal swab sample; measuring a cancer biomarker panel using the cDNA, wherein the cancer biomarker panel comprises three or more biomarkers selected from the group consisting of COX1, GROα, GROγ, PPARγ, p21, and cycD; applying the measured cancer biomarker panel from the subject against a database of measured cancer biomarker panels from control subjects, wherein the database is stored on a computer system; determining that the subject has an increased risk of having colorectal cancer by measuring a change of at least 15% in the cancer biomarker panel relative to measured cancer biomarker panels from control subjects.