| 摘要 |
Discloses an isolated binding molecule, capable of specifically binding to an epitope in the stem region of the hemagglutinin protein (HA) of influenza A virus subtypes of phylogenetic group 1 and influenza A virus subtypes of phylogenetic group 2 subtypes, and capable of neutralizing influenza A virus subtypes of phylogenetic group 1 and phylogenetic group 2, characterized in that the binding molecule is also capable of specifically binding to the hemagglutinin protein (HA) of influenza B virus subtypes, wherein the binding molecule is selected from the group consisting of: a binding molecule comprising a heavy chain CDR1 region of SEQ ID NO:139, a heavy chain CDR2 region of SEQ ID NO:134, and a heavy chain CDR3 region of SEQ ID NO:145, and a light chain CDR1 region of SEQ ID NO: 146, a light chain CDR2 region of SEQ ID NO: 174, and a light chain CDR3 region of SEQ ID NO: 147, a binding molecule comprising a heavy chain CDR1 region of SEQ ID NO:139, a heavy chain CDR2 region of SEQ ID NO:134, and a heavy chain CDR3 region of SEQ ID NO:145, and a light chain CDR1 region of SEQ ID NO: 148, a light chain CDR2 region of SEQ ID NO: 149, and a light chain CDR3 region of SEQ ID NO: 150, a binding molecule comprising a heavy chain CDR1 region of SEQ ID NO:139, a heavy chain CDR2 region of SEQ ID NO:134, and a heavy chain CDR3 region of SEQ ID NO:145, and a light chain CDR1 region of SEQ ID NO: 142, a light chain CDR2 region of SEQ ID NO: 143, and a light chain CDR3 region of SEQ ID NO: 173; and a binding molecule comprising a heavy chain CDR1 region of SEQ ID NO:139, a heavy chain CDR2 region of SEQ ID NO:134, and a heavy chain CDR3 region of SEQ ID NO:152, and a light chain CDR1 region of SEQ ID NO: 148, a light chain CDR2 region of SEQ ID NO: 149, and a light chain CDR3 region of SEQ ID NO: 150, a binding molecule comprising a heavy chain CDR1 region of SEQ ID NO:139, a heavy chain CDR2 region of SEQ ID NO:134, and a heavy chain CDR3 region of SEQ ID NO:152, and a light chain CDR1 region of SEQ ID NO: 156, a light chain CDR2 region of SEQ ID NO: 157, and a light chain CDR3 region of SEQ ID NO: 158, an antibody or antigen-binding fragment thereof comprising a heavy chain CDR1 region of SEQ ID NO:139, a heavy chain CDR2 region of SEQ ID NO:134, and a heavy chain CDR3 region of SEQ ID NO:152, and a light chain CDR1 region of SEQ ID NO: 171, a light chain CDR2 region of SEQ ID NO: 164, and a light chain CDR3 region of SEQ ID NO: 172, and a binding molecule comprising a heavy chain CDR1 region of SEQ ID NO:139, a heavy chain CDR2 region of SEQ ID NO:134, and a heavy chain CDR3 region of SEQ ID NO:152, and a light chain CDR1 region of SEQ ID NO: 142, a light chain CDR2 region of SEQ ID NO: 143, and a light chain CDR3 region of SEQ ID NO: 144; wherein the sequences are as defined in the complete specification. Also discloses use of such binding molecules for diagnostic, prophylactic, or therapeutic treatment of influenza. |
