| 发明名称 |
PROCESS FOR THE PREPARATION OF APIXABAN |
| 摘要 |
A crystalline Form N-1 of apixaban substantially free from one or more of: 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid; 7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-1-phenyl-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; or methyl 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate, relative to apixaban by area percentage of HPLC and having a mean particle size equal to or greater than 100 μm. |
| 申请公布号 |
US2016143894(A1) |
申请公布日期 |
2016.05.26 |
| 申请号 |
US201514950430 |
申请日期 |
2015.11.24 |
| 申请人 |
Cadila Healthcare Limited |
发明人 |
KHERA Brij;SINGH Kumar Kamlesh;DIWAKAR Santosh Devidas;NARODE Sunil Dnyaneshwar;SUTHAR Hiteshkumar Natwarlal |
| 分类号 |
A61K31/451;A61K45/06 |
主分类号 |
A61K31/451 |
| 代理机构 |
|
代理人 |
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| 主权项 |
1. A crystalline Form N-1 of apixaban substantially free from one or more of: 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid; 7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-1-phenyl-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; or methyl 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate, relative to apixaban by area percentage of HPLC and having a mean particle size equal to or greater than 100 μm. |
| 地址 |
Ahmedabad IN |
