发明名称 PROCESS FOR THE PREPARATION OF AN ANTIDEPRESSANT AND THE INTERMEDIATES THEREOF
摘要 The present invention relates to a process for the preparation of 1-[2-(2,4-dimethylphenylsulphanyl)phenyl]piperazine of formula (I), also known as vortioxetine, salts thereof, and intermediates useful for its synthesis.
申请公布号 US2016145224(A1) 申请公布日期 2016.05.26
申请号 US201514945654 申请日期 2015.11.19
申请人 DIPHARMA FRANCIS s.r.l. 发明人 GIANNOTTI Luca;GRAZIOSI Renzo;ATTOLINO Emanuele;ALLEGRINI Pietro
分类号 C07D295/096;C07D241/08;C07C309/66 主分类号 C07D295/096
代理机构 代理人
主权项 1. A process for preparing a compound of formula (III), or a salt thereof, wherein Z is H or an amino protecting group, comprising reacting a compound of formula (IV), or a salt thereof, wherein each of R substituents is an aldehyde group —CHO; or each of R substituents, being the same or different, is a carboxy group COOH or a reactive derivative thereof, or a —CH2X group, wherein X is an halogen atom or a good leaving group, with a compound of formula (V), or a salt thereof, NH2—Z   (V) wherein Z is as defined above, and, if the case, converting a compound of formula (III) into another compound of formula (III) or a salt thereof, and/or converting a salt of a compound of formula (III) into its free base.
地址 Baranzate IT