SYSTEMS AND METHODS FOR DIAGNOSIS OF EPITHELIAL LESIONS

摘要

Systems comprising an optical fiber switch connected to a light source and an optical fiber probe, the optical fiber probe comprising a first optical fiber connected to the optical fiber switch and a second optical fiber connected to a spectrophotometer. Methods for determining one or more tissue parameters comprising: emitting light from a first optical fiber into a tissue; collecting the light reemitted from the tissue with a second optical fiber; generating a spectra of the light reemitted from the tissue with a spectrophotometer; and utilizing a look-up table based algorithm to determine one or more tissue parameters, wherein the lookup-table based algorithm comprises the steps of: generating a look-up table by measuring the functional form of a reflectance measured by the spectrophotometer using one or more calibration standards with known optical properties; and implementing an iterative fitting routine based on the lookup-table.

主权项

1. A system comprising:
an optical fiber probe comprising a first optical fiber and a second optical fiber; a light source connected to the first optical fiber; a spectrophotometer connected to the second optical fiber; and a software interface connected to the spectrophotometer, wherein:
the software interface comprises a lookup table;the lookup table comprises a matrix of a diffuse reflectance mapped against known optical properties of one or more calibration standards; andthe diffuse reflectance is not mapped against a wavelength of light in the matrix.