| 发明名称 |
METHODS OF GENERATING CELLS WITH MULTILINEAGE POTENTIAL |
| 摘要 |
The present invention relates to methods for generating mammalian multilineage-potential cells, including mesenchymal stem cells, comprising contacting mammalian somatic cells exhibiting a mature phenotype with PDGF-AB or functional derivative, fragment or mimetic thereof and Azacitidine or functional derivative or analogue thereof for a time and under conditions sufficient to induce the transition of the somatic cells to cells exhibiting multilineage differentiative potential. Also provided are uses of said multilineage-potential cells, such as in promoting tissue repair and regeneration. |
| 申请公布号 |
US2016145575(A1) |
申请公布日期 |
2016.05.26 |
| 申请号 |
US201314652552 |
申请日期 |
2013.12.17 |
| 申请人 |
NEWSOUTH INNOVATIONS PTY LIMITED |
发明人 |
PIMANDA John;CHANDRAKANTHAN Vashe |
| 分类号 |
C12N5/0775;A61L27/38;A61K31/706;A61K35/28;A61K38/18 |
主分类号 |
C12N5/0775 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of generating a mammalian multilineage-potential cell, said method comprising contacting a mammalian somatic cell exhibiting a mature phenotype with PDGF-AB or functional derivative, fragment or mimetic thereof and Azacitidine or functional derivative or analogue thereof for a time and under conditions sufficient to induce the transition of said somatic cell to a cell exhibiting multilineage differentiative potential. |
| 地址 |
Sydney AU |
