摘要 |
The present invention provides a compound of Formula (I) wherein R1, R2, R3 and R4 are independently H or C1-6 alkyl, provided that when R1, R2, and R3 are H, R4 is C1-6 alkyl, and when R1, R2, and R4 are H, R3 is C1-6 alkyl, and when R1, R3, and R4 are H, R2 is C1-6 alkyl, and when R2, R3, and R4 are H, R is C1-6 alkyl; and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. |
申请人 |
MERCK SHARP & DOHME CORP.;MOCHIDA PHARMACEUTICAL CO., LTD. |
发明人 |
SMITH, CAMERON, JAMES;TAN, JOHN, QIANG;ZHANG, TING;BALKOVEC, JAMES;GREENLEE, WILLIAM, JOHN;GUO, LIANGQIN;CHEN, YI-HENG;CHEN, YILI;CHACKALAMANNIL, SAMUEL;HIRABAYASHI, TOMOKAZU;KATSUNO, MIKA |