发明名称 |
DIAGNOSTIC IN VITRO METHOD |
摘要 |
Disclosed is a diagnostic in vitro method for determining the activity of thiopurine S-methyltransferase (TPMT) in individuals to be examined, characterized in that the content of urothione and/or jukathione in body fluids is determined. Also disclosed is a diagnostic in vitro method for determining the TPMT activity in cellular extracts of test subjects of any origin, characterized in that molybdenum cofactor (Moco) and/or decomposition stages of Moco are used as substrates for the reaction and the formed quantity of jukathione and/or urothione is determined. Finally, a diagnostic in vitro method is disclosed, wherein urothione and/or jukathione serves as a biomarker for an increased susceptibility with regard to one or more particular diseases, which is determined in body fluids and/or cellular extracts. |
申请公布号 |
EP3022315(A1) |
申请公布日期 |
2016.05.25 |
申请号 |
EP20140738530 |
申请日期 |
2014.07.14 |
申请人 |
UNIVERSITÄT ZU KÖLN;ROBERT BOSCH GESELLSCHAFT MBH FÜR MEDIZINISCHE FORSCHUNG |
发明人 |
SCHWARZ, GÜNTER;CSASZAR, JULIKA;SCHAEFFELER, ELKE;SCHWAB, MATTHIAS |
分类号 |
C12Q1/48 |
主分类号 |
C12Q1/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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