FUMARIC ACID DERIVATIVES FOR MEDICAL USE

摘要

An object of the present invention relates to fumaric acid derivatives which are useful in the protection of neuronal necrosis and inflammation, particular in the brain. It is a particular object of the present invention to protect against such conditions during or in connection with stroke, hypoxia or vasoconstriction. Thus, one aspect of the present invention is fumaric acid derivatives for use in the prevention or treatment of a condition selected from the group consisting of neuronal necrosis and an inflammatory condition. Another aspect of the present invention relates to a pharmaceutical composition comprising a fumaric acid derivative, a medicament selected from the group consisting of thrombolytic agents, fibrinolytic agents, anti-thrombotic agents, anti-platelet aggregation agents, anticoagulants, anti-hypertensive agents, anti-diabetic agents, anti-dyslipidemia agents, cholesterol reducing agents, statins, and a pharmaceutically acceptable carrier.