发明名称 |
SUPPRESSION OF ITCH |
摘要 |
The invention provides a polypeptide, for use in suppressing or treating itch, wherein the polypeptide comprises: a non-cytotoxic protease, which protease is capable of cleaving a SNARE protein in an itch-specific DRG neuron or a pruriceptor; a Targeting Moiety (TM) that is capable of binding to a Binding Site on the itch-specific DRG neuron or a pruriceptor, which Binding Site is capable of undergoing endocytosis to be incorporated into an endosome within the itch-specific DRG neuron or a pruriceptor, and wherein said itch-specific DRG neuron or a pruriceptor expresses said SNARE protein; and a translocation domain that is capable of translocating the protease from within an endosome, across the endosomal membrane and into the cytosol of the itch-specific DRG neuron or a pruriceptor; with the proviso that the polypeptide is not a clostridial neurotoxin (holotoxin) molecule. |
申请公布号 |
US2016137999(A1) |
申请公布日期 |
2016.05.19 |
申请号 |
US201414900892 |
申请日期 |
2014.07.09 |
申请人 |
IPSEN BIOINNOVATION LIMITED |
发明人 |
FOSTER Keith |
分类号 |
C12N9/52;C07K7/08 |
主分类号 |
C12N9/52 |
代理机构 |
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代理人 |
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主权项 |
1. A polypeptide, for use in suppressing or treating itch, wherein the polypeptide comprises:
(i) a non-cytotoxic protease, which protease is capable of cleaving a SNARE protein in an itch-specific DRG neuron or a pruriceptor; (ii) a Targeting Moiety (TM) that is capable of binding to a Mas-related G protein-coupled receptor (Mrgpr) on the itch-specific DRG neuron or a pruriceptor, which Mrgpr is capable of undergoing endocytosis to be incorporated into an endosome within the itch-specific DRG neuron or a pruriceptor, and wherein said itch-specific DRG neuron or a pruriceptor expresses said SNARE protein; and (iii) a translocation domain that is capable of translocating the protease from within an endosome, across the endosomal membrane and into the cytosol of the itch-specific DRG neuron or a pruriceptor; with the proviso that the polypeptide is not a clostridial neurotoxin (holotoxin) molecule. |
地址 |
Abingdon, Oxfordshire GB |