发明名称 |
THY1 (CD90) AS A NOVEL THERAPY TO CONTROL ADIPOSE TISSUE ACCUMULATION |
摘要 |
The present invention relates to methods of treating a condition involving excessive adipogenesis. This method relates to selecting a subject having a condition involving excessive adipogenesis and administering to the selected subject a composition comprising a Thy1 protein or polypeptide fragment thereof, or an agent that enhances Thy1 expression, under conditions effective to treat the condition. The present invention also relates to isolated nucleic acid molecules encoding a Thy1 protein or the fragment thereof and pharmaceutical formulations including such a protein or fragment thereof or an agent that enhances Thy1 expression and a pharmaceutically acceptable carrier. The present invention also relates to methods of inhibiting adipogenesis and/or decreasing adipocyte size, as well as methods of screening a candidate compound for its ability to influence adipogenesis. |
申请公布号 |
EP2908853(A4) |
申请公布日期 |
2016.05.18 |
申请号 |
EP20130847469 |
申请日期 |
2013.10.21 |
申请人 |
UNIVERSITY OF ROCHESTER |
发明人 |
PHIPPS, RICHARD, P.;WOELLER, COLLYNN, F.;FELDON, STEVEN, E. |
分类号 |
A61K38/17;C07K14/705 |
主分类号 |
A61K38/17 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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