发明名称 |
DIAGNOSIS, PROGNOSIS AND TREATMENT OF INFLAMMATORY BOWEL DISEASES |
摘要 |
The invention relates to methods comprising a step consisting of determining the proportion and/or the level of T regulatory lymphocytes with a CD4+ CD8ααlow Foxp3neg phenotype specific for Faecalibacterium prausnitzii for (i) diagnosing, (ii) prognosing outcome of, or (iii) predicting the risk of developing, an inflammatory bowel disease in a patient. The invention also concerns the treatment of an inflammatory bowel disease. The invention further relates to the kits that are useful in the above methods for diagnosing/prognosing an inflammatory bowel disease, and in the treatment of an inflammatory bowel disease. In a particular embodiment, the inflammatory bowel disease is the Crohn's disease. |
申请公布号 |
EP3019864(A1) |
申请公布日期 |
2016.05.18 |
申请号 |
EP20140738517 |
申请日期 |
2014.07.11 |
申请人 |
INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE (INSERM);CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.);UNIVERSITÉ D'ANGERS;UNIVERSITE DE NANTES;CHU NANTES;UNIVERSITÉ PIERRE ET MARIE CURIE (PARIS 6);ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS |
发明人 |
JOTEREAU, FRANCINE;SOKOL, HARRY;BOSSARD, CÉLINE;ALTARE, FREDERIC;SARRABAYROUSE, GUILLAUME |
分类号 |
G01N33/50 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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