| 发明名称 | Targeted contrast agents and methods for targeting contrast agents | ||
| 摘要 | A contrast agent having a contrast protein have contrast properties and at least one targeting moiety, wherein the at least one targeting moiety is operatively linked to or incorporated within the contrast protein. Methods for targeting contrast agents and for preparing such agents are included. | ||
| 申请公布号 | US9339559(B2) | 申请公布日期 | 2016.05.17 |
| 申请号 | US200611530398 | 申请日期 | 2006.09.08 |
| 申请人 | Georgia State University Research Foundation, Inc. | 发明人 | Yang Jenny J.;Liu Zhi-Ren |
| 分类号 | A61K49/00;A61K6/00;A61K38/02;A61K49/08;A61K49/14 | 主分类号 | A61K49/00 |
| 代理机构 | Thomas Horstemeyer, LLP | 代理人 | Thomas Horstemeyer, LLP |
| 主权项 | 1. A recombinant protein comprising: domain 1 of a CD2 protein, where the domain 1 is modified to contain a paramagnetic metal binding site, the paramagnetic metal binding site comprising: at least three mutations in domain 1 of the CD2 protein, where the at least three mutations are N15E, L58D, and K64D; and a targeting moiety, where the targeting moiety is operatively linked to the domain 1 of the CD2 protein, wherein the recombinant protein has contrast properties. | ||
| 地址 | Atlanta GA US | ||