Methods and compositions for inhibiting CNKSR1

摘要

Embodiments include compositions and methods of inhibiting CNKSR1 and methods of identifying inhibitors of CNKSR1.

主权项

1. A compound of Formula IIA: wherein R4 is —H, —C1-C4alkyl, R5 is —C1-C4alkyl-OH, —C2-C6alkenyl-OH, C1-C4alkykl-C(O)—C1-C4alkyl, —C2-C6alkenyl-C(O)—C1-C4alkyl, —C1-C4alkykl-C(O)—C3-C5cycloalkyl, —C2-C6alkenyl-C(O)—C3-C5cycloalkyl, R8 is C1-C4alkyl, or —C3-C5 cycloalkyl; R7 is H or or a pharmaceutically acceptable salt thereof.