PROCESS FOR MAKING CRYSTALS VIA ULTRASONIC IRRADIATION OF A CLOSED LOOP

摘要

A process for preparing crystalline particles of an active principal in the presence of ultrasonic irradiation that comprises contacting a solution of a solute in a solvent in a first flowing stream with an anti-solvent in a second flowing stream causing the mixing thereof, wherein the flow rate ratio of the anti- solvent: solvent is higher than 20:1, and collecting crystals that are generated.