| 发明名称 | Methods and compositions for modulating MIR-204 activity | ||
| 摘要 | The present invention provides compositions and methods for regulating insulin production. | ||
| 申请公布号 | US9334498(B2) | 申请公布日期 | 2016.05.10 |
| 申请号 | US201314400292 | 申请日期 | 2013.05.10 |
| 申请人 | UAB Research Foundation | 发明人 | Shalev Anath;Xu Guanlan |
| 分类号 | C12N15/113;A61K31/70 | 主分类号 | C12N15/113 |
| 代理机构 | Myers Bigel & Sibley, P.A. | 代理人 | Myers Bigel & Sibley, P.A. |
| 主权项 | 1. A method of increasing insulin production in a cell that produces insulin, comprising contacting the cell with a microRNA-204 (miR-204)antagonist, thereby increasing insulin production in the cell, wherein the miR-204 antagonist comprises an oligonucleotide that binds to and inhibits or reduces the expression and/or activity of miR-204 or pre-miR-204. | ||
| 地址 | Birmingham AL US | ||