Method for treating pulmonary disorders with liposomal amikacin formulations

摘要

Disclosed herein are methods of treating pulmonary disorders comprising administering to the patient an effective dose of a nebulized liposomal amikacin formulation for at least one treatment cycle, wherein: the treatment cycle comprises an administration period of 15 to 75 days, followed by an off period of 15 to 75 days; and the effective dose comprises 100 to 2500 mg of amikacin daily during the administration period.

主权项

1. A method of treating a Pseudomonas pulmonary infection in a patient in need thereof, comprising administering to the lungs of the patient for at least one treatment cycle, an effective dose of a nebulized liposomal amikacin formulation comprising amikacin encapsulated in a liposome wherein the lipid component of the liposome comprises a phosphatidylcholine and a sterol, wherein:
the treatment cycle comprises an administration period of 15 to 35 days followed by an off period of 15 to 75 days: during which an improvement in lung function is maintained for the patient, for at least 15 days after the administration period ends, and the effective dose comprises 510 mg to 610 mg of amikacin daily during the administration period.