发明名称 |
METHODS OF DETERMINING SEROTYPE SPECIFICITY OF AN ANTIBODY |
摘要 |
Methods of determining serotype specificity of an antibody that binds to a serotype of a pathogen are provided. Aspects of the methods include producing an assay mixture and evaluating the assay mixture for the presence of an antibody-pathogen-detectable label binding complex to determine the serotype specificity of the antibody. The assay mixture includes the antibody, at least first and second serotypes of the pathogen, a first detectable label that specifically binds to the first serotype of the pathogen, and a second detectable label that specifically binds to the second serotype of the pathogen. The methods find use in a variety of applications, such as for example determining the serotype specificity and/or cross reactivity of an antibody (e.g., an anti-dengue virus antibody). |
申请公布号 |
WO2016070023(A1) |
申请公布日期 |
2016.05.06 |
申请号 |
WO2015US58281 |
申请日期 |
2015.10.30 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
HARRIS, EVA;HADJILAOU, ALEXANDROS;GREEN, ANGELA MARIE;COLOMA, MARIA JOSEFINA |
分类号 |
G01N33/53;C12Q1/02;G01N33/533;G01N33/543 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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