| 摘要 |
The present invention relates to the use of compounds with at least one metal-sensitive chemical shift for determining metal concentrations and/or measuring metal concentration changes, by quantifying the NMR signal corresponding to said metal-specific chemical shift, preferably its intensity, frequency and/or bandwidth, wherein the compound is selected from the group of pyro-EGTA, EGTA, EDTA, AATA, APTRA, BAPTA, HIDA, citrate, CarboxyGlutamate (CGlu), arylazo chromotopic acid, beta-diketone (crown-ether), mono-, di-, or tri-pyridyl aniline, mono-, di-, or tri-pyridyl amine, trimethylphenylammonium, or derivatives thereof. The present invention also relates to methods of diagnosing and/or monitoring treatment of a disease causing changes in metal concentrations. |
