Attenuated Swine Influenza Vaccines and Methods of Making and Use Thereof

摘要

This disclosure provides attenuated swine influenza strains, particularly those produced via a reverse genetics approach, compositions comprising same, and methods of production and use thereof. The attenuated strains are engineered to encode HA proteins having additional glycosylation sites, relative to the HA proteins encoded by the corresponding virulent parental viruses. Advantageously, the attenuated influenza strains may be administered

主权项

1. An attenuated swine influenza strain capable of providing a safe and effective immune response in porcine against influenza or diseases caused by influenza.