发明名称 |
THERAPEUTIC MANNAN LINKED MYLEIN BASIC PROTEIN PEPTIDE MBP83-99 |
摘要 |
A first aspect of the invention relates to a conjugate comprising: (i) mannan; and (ii) at least one epitope comprising a peptide fragment of a protein selected from myelin basic protein (MBP), myelin oligodentrocyte glycoprotein (MOG) and proteolipid protein (PLP), said peptide fragment being in linear or cyclic form; wherein said epitope is linked to mannan via a[(LyS-Gly)n] bridge, where n is an integer from 1 to 10. Further aspects of the invention relate to pharmaceutical compositions comprising said conjugates, and their use in the preparation of a medicament for treating an immune disorder. |
申请公布号 |
EP2240200(B1) |
申请公布日期 |
2016.05.04 |
申请号 |
EP20090703874 |
申请日期 |
2009.01.22 |
申请人 |
VIANEX S.A. |
发明人 |
MATSOUKAS, JOHN;TSELIOS, THEODORE;APOSTOLOPOULOS, VASSO;TSEVELEKI, VIVIAN;KATSARA, MARIA;PROBERT, LESLEY |
分类号 |
A61K39/00;A61K39/39;A61K47/36;A61K47/48;C07K14/47 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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