发明名称 |
METHODS AND ORGANISMS FOR THE GROWTH-COUPLED PRODUCTION OF 1,4-BUTANEDIOL |
摘要 |
The invention provides a non-naturally occurring microorganism comprising one or more gene disruptions, the one or more gene disruptions occurring in genes encoding an enzyme obligatory to coupling 1,4-butanediol production to growth of the microorganism when the gene disruption reduces an activity of the enzyme, whereby theone or more gene disruptions confers stable growth-coupled production of 1,4-butanediol onto the non-naturally occurring microorganism. The microorganism can further comprise a gene encoding an enzyme in a 1,4-butanediol (BDO) biosynthetic pathway. The invention additionally relates to methods of using microorganisms to produce BDO. |
申请公布号 |
EP2185708(B1) |
申请公布日期 |
2016.05.04 |
申请号 |
EP20080782639 |
申请日期 |
2008.08.06 |
申请人 |
GENOMATICA, INC. |
发明人 |
BURGARD, ANTHONY, P.;VAN DIEN, STEPHEN, J.;BURK, MARK, J. |
分类号 |
C12N15/52;C12N1/00;C12P7/18 |
主分类号 |
C12N15/52 |
代理机构 |
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代理人 |
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地址 |
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