发明名称 |
Oligomer-contained nanoparticle complex release system |
摘要 |
An oligomer-contained nanoparticle complex is provided. The oligomer-contained nanoparticle complex of the invention comprises (a) a nanoparticle, (b) a polymer with high molecule weigh, (c) a target molecule, (d) an oligomer, wherein the oligomer is crosslinked with the polymer by the intermolecular hydrogen bonds or electron bonds, and e) a space for active substances, wherein the space for active substances is encapsulated by the nanoparticle. The oligomer-contained nanoparticle complex of the invention has the high stability and fast drug release rate, and would not be largely accumulated in normal tissues. The invention also provides a method for preparing the oligomer-contained nanoparticle complex and the method for releasing drug. |
申请公布号 |
US9326938(B2) |
申请公布日期 |
2016.05.03 |
申请号 |
US201314100425 |
申请日期 |
2013.12.09 |
申请人 |
NATIONAL YANG MING UNIVERSITY |
发明人 |
Lo Chun-Liang;Chiang Yi-Ting;Cheng Yung-Ting;Lu Chi-Yang |
分类号 |
A61K9/14;A61K9/127;A61K31/704;A61K9/00;A61K47/48 |
主分类号 |
A61K9/14 |
代理机构 |
Muncy, Geissler, Olds & Lowe, P.C. |
代理人 |
Muncy, Geissler, Olds & Lowe, P.C. |
主权项 |
1. An oligomer-contained nanoparticle complex, comprising:
a) a nanoparticle; b) a polymer, wherein the polymer is an amphiphilic polymer having a hydrophilic and a hydrophobic group, and the hydrophobic group is inserted on the outside of the nanoparticle; c) a targeting molecule, wherein an end of the targeting molecule is bonded with the hydrophilic segment of the polymer by intermolecular hydrogen bonds; d) an oligomer, wherein the oligomer is hydrophilic or charged, and two ends of the oligomer are conjugated by covalent bonds with the targeting molecule, and e) a space for active substances, wherein the space for active substances is encapsulated by the nanoparticle. |
地址 |
Taipei TW |