| 主权项 |
1. A single-step, one pot process for preparation of α-acyloxy carbonyl compound of general formula (I) wherein R is selected from H, alkyl, aryl, Bn; R1 is selected from H, alkyl, substituted aryl, unsubstituted aryl —CH2OTBS (TBS=Tertiary butyl silyl), —CH2OBn, —OR, OMOM (Methoxy methelene); Ar is selected from substituted aromatic, unsubstituted aromatic or heteroaromatic; R and R1 Optionally can combine to form a ring structure; comprising the steps of:
i) reacting alkene of formula (III) with an aldehyde of formula (IV) in the presence of a N-Heterocyclic carbene catalyst (NHC), a halogen source, tri-ethyl amine and a solvent in oxygen atmosphere at a temperature in the range of 15-30° C. by stirring for period in the range of 10-50 hours to obtain compound of general formula (I); wherein R is selected from H, alkyl, aryl, Bn; R1 is selected from H, alkyl, substituted aryl, unsubstituted aryl —CH2OTBS (TBS=Tertiary butyl silyl), —CH2OBn, —OR, OMOM (Methoxy methelene); Ar is selected from substituted aromatic, unsubstituted aromatic or heteroaromatic. |
