发明名称 NOVEL COMPOSITION AND SOLUTION WITH CONTROLLED CALCIUM ION LEVEL, AND RELATED METHOD AND USE FOR REPERFUSION
摘要 A solution comprises a preservation mixture comprising a calcium ion source; and a buffer for maintaining a pH of the solution. The molar concentration of calcium ion (Ca2+) in the solution is from 0.18 to 0.26 mmol/L, and the pH is lower than 7.4 and higher than 6.6. A composition for preparing the solution may comprise adenosine, lidocaine, and a calcium source, wherein the molar ratio of adenosine:calcium is from 0.3:0.26 to 0.45:0.18, and the molar ratio of lidocaine:calcium is from 0.04:0.26 to 0.09:0.18. A donor heart may be reperfused with the solution. The solution may be used for reperfusion of a donor heart, such as at a temperature from about 25 to about 37 °C. The donor may be a donor after circulatory death.
申请公布号 WO2016061700(A1) 申请公布日期 2016.04.28
申请号 WO2015CA51084 申请日期 2015.10.23
申请人 UNIVERSITY OF MANITOBA 发明人 WHITE, CHRISTOPHER;FREED, DARREN
分类号 A01N1/02 主分类号 A01N1/02
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