发明名称 4'-O-SUBSTITUTED ISOINDOLINE DERIVATIVES AND COMPOSITIONS COMPRISING THE SAME AND METHODS OF USING THE SAME
摘要 PROBLEM TO BE SOLVED: To provide safe and effective compounds for treating, preventing and managing cancer and other diseases and conditions.SOLUTION: The present invention provides a compound represented by the following formula, or pharmaceutically acceptable salt, solvate, prodrug, clathrate or stereoisomer thereof, where Y is C=O or CH2; R1 is H, alkyl, alkenyl, alkynyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, heteroarylalkyl, arylaminocarbonyl, alkylcarbonyl or the like, and R1 is optionally substituted by one or more groups selected from alkoxy, halo, alkyl, carboxy, alkylaminocarbonyl, alkoxycarbonyl, nitro, amine, nitrile, haloalkyl, hydroxy or alkylsulfonyl.SELECTED DRAWING: None
申请公布号 JP2016065067(A) 申请公布日期 2016.04.28
申请号 JP20150211991 申请日期 2015.10.28
申请人 CELGENE CORP 发明人 ALEXANDER L RUCHELMAN;MULLER GEORG W;MAN HON-WAH
分类号 C07D401/04;A61P43/00;C07D401/14;C07D405/14;C07D409/14 主分类号 C07D401/04
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