Treatment of Insulin Resistance Through Inhibitors of Transcription Factor TSC22D4

摘要

The present invention relates to modulators, in particular inhibitors, of TSC22D4 activity or expression and their uses for the prevention, treatment, and/or regulation of insulin resistance, metabolic syndrome and/or diabetes and/or for improving insulin sensitivity in mammal. The present invention further relates to screening methods in order to identify these modulators, the use of modulators as identified in the diagnosis of these diseases, as well as kits, comprising materials for performing the methods according to the present invention.

主权项

1. A method for identifying a modulator for the prevention, treatment, and/or regulation of insulin resistance, metabolic syndrome and/or diabetes type 1 or 2, and/or for improving insulin sensitivity, wherein said method comprises the steps of:
a) providing a biological sample, comprising a nucleic acid sequence encoding TSC22D4 or the gene expression product of TSC22D4, b) contacting said sample with at least one putative modulator of said nucleic acid sequence encoding TSC22D4 or the gene expression product of TSC22D4, and c) detecting a binding between said at least one putative modulator and said nucleic acid sequence encoding TSC22D4 or the gene expression product of TSC22D4, and d) identifying said modulator of said nucleic acid sequence encoding TSC22D4 or the gene expression product of TSC22D4.