发明名称 |
MODIFIED TEMPLATE-INDEPENDENT ENZYMES FOR POLYDEOXYNUCLEOTIDE SYSTHESIS |
摘要 |
The invention includes methods for identifying polymerases, such as modified terminal nucleotidyl transferases (TdT), that are capable of binding nucleotides comprising removable 3'- O-blocking moieties to a nucleic acid initiator, without the use of a template. The invention further includes the identified polymerases, and methods of using the polymerases for de novo synthesis of predetermined oligonucleotide sequences. |
申请公布号 |
WO2016064880(A1) |
申请公布日期 |
2016.04.28 |
申请号 |
WO2015US56467 |
申请日期 |
2015.10.20 |
申请人 |
MOLECULAR ASSEMBLIES, INC. |
发明人 |
EFCAVITCH, WILLIAM, J.;SYLVESTER, JULIESTA, E. |
分类号 |
C12N15/54 |
主分类号 |
C12N15/54 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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