发明名称 |
Milk fat globule epidermal growth factor—factor VIII and sepsis |
摘要 |
Provided are methods of treating a mammal undergoing sepsis or at risk for sepsis. Also provided are methods of preventing or treating a physiologic effect of sepsis in a mammal. Additionally provided is the use of milk fat globule epidermal growth factor-factor VIII (MFG-E8) for the manufacture of a medicament for preventing or treating a physiologic effect of sepsis in a mammal, and the use of milk fat globule epidermal growth factor-factor VIII (MFG-E8) for the treatment of a mammal having sepsis or at risk for sepsis. |
申请公布号 |
US9321822(B2) |
申请公布日期 |
2016.04.26 |
申请号 |
US200611920304 |
申请日期 |
2006.05.12 |
申请人 |
The Feinstein Institute for Medical Research |
发明人 |
Wang Ping |
分类号 |
C07K14/435;A61K38/18;C07K14/705;A61K38/00 |
主分类号 |
C07K14/435 |
代理机构 |
Amster, Rothstein & Ebenstein LLP |
代理人 |
Amster, Rothstein & Ebenstein LLP |
主权项 |
1. A method of reducing thymocyte apoptosis in sepsis in a human, the method comprising administering to the human at least 20 μg/kg body weight (BW) an amount of a milk fat globule epidermal growth factor-factor VIII (MFG-E8), wherein the MFG-E8 has an amino acid sequence at least 99% identical to SEQ ID NO:1, and wherein the MFG-E8 is administered by intravenous administration. |
地址 |
Manhasset NY US |