Sorbent for removing protein-bound substances

摘要

The invention relates to a sorption agent having improved selectivity properties for removing protein-bound substances from a biological fluid, in particular blood or blood plasma of patients having severe disturbances of the liver function or liver failure and having kidney insufficiency, thee sorption agent having: (a) a porous, neutral, hydrophobic polymer and (b) a polypeptide layer adsorbed on the polymer, the neutral, hydrophobic polymer having a mean pore size of at least 15 nm. Furthermore, the invention relates to methods and uses in connection with such a sorption agent. The invention is used in particular in extracorporeal liver support.

主权项

1. A sorption agent for removing protein-bound substances from a biological fluid with reduced adsorption of Protein C, the sorption agent comprising:
(a) a porous, neutral, hydrophobic polymer including microparticles, where the microparticles have a particle size of 20 μm or less and (b) a polypeptide layer adsorbed on the polymer, wherein the neutral, hydrophobic polymer is a styrene/divinyl benzene copolymer and has a mean pore size of 30-40 nm, wherein the polypeptide layer comprises at least one type of polypeptide selected from albumin, in particular human albumin, and albumin-like polypeptides, and wherein a 10% polypeptide solution is used for the adsorptive coating of the neutral, hydrophobic polymer with the polypeptide layer.