Controlled release and taste masking oral pharmaceutical compositions

摘要

The invention relates to an oral pharmaceutical composition comprising an active agent, a macroscopically homogeneous structure and a gastro-resistant coating. The macroscopically homogeneous structure comprises at least one hydrophilic compound and at least one lipophilic compound and/or at least one amphiphilic compound. The macroscopically homogeneous structure controls the release of the active ingredient, and the gastro-resistant film prevents release of the active agent in the stomach.

主权项

1. A controlled release oral pharmaceutical composition comprising:
(i) budesonide in an amount effective to treat intestinal inflammatory disease; (ii) a macroscopically homogenous structure comprising:
(a) at least one lipophilic compound and(b) at least one hydrophilic compound,wherein the macroscopically homogenous structure controls the release of the budesonide; and (iii) a gastro-resistant coating on the macroscopically homogenous structure that prevents release of budesonide in the stomach, wherein the macroscopically homogenous structure is a tablet.