| 摘要 |
This disclosure relates to selectin inhibitors, compositions, and methods related thereto. In certain embodiments, the disclosure relates to glycopeptides that contain one more modified amino acids conjugated to a saccharide or polysaccharide. In certain embodiments, the disclosure relates to uses of the glycopeptides as anti-inflammatory, anti-thrombotic, or anti-metastatic agents. |
| 主权项 |
1. An isolated glycopeptide comprising Y1X1Y2X2X3Y3X4X5X6Z1X7W1 (SEQ ID NO: 1) or salts thereof, wherein
W1 is threonine or serine substituted with a saccharide or polysaccharide X1, X2, X3, X4, X5, X6, and X7 individually and independently any amino acid, Y1, Y2, and Y3 are each individually and independently tyrosine, phenylalanine, or phenylglycine unsubstituted or substituted with —SO3H, —CH2SO3H, —CF2SO3H, —CO2H, —CONH2, —NHSO2CH3, —SO2NH2, or —CH2PO3H, and Z1 is proline or hydroxyproline. |
