| 发明名称 |
METHODS OF TREATING CANCER |
| 摘要 |
Methods of treating cancers comprising administering a fibroblast growth factor receptor 1 (FGFR1) extracellular domain (ECD) and/or an FGFR1 ECD fusion molecule are provided. Methods of treating cancers comprising administering a fibroblast growth factor receptor 1 (FGFR1) extracellular domain (ECD) and/or an FGFR1 ECD fusion molecule and at least one anti-angiogenic agent are provided. |
| 申请公布号 |
US2016106809(A1) |
申请公布日期 |
2016.04.21 |
| 申请号 |
US201414890047 |
申请日期 |
2014.05.22 |
| 申请人 |
FIVE PRIME THERAPEUTICS, INC. ;GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED |
发明人 |
Bellovin David;Baker Kevin;Brennan Thomas;Pandite Arundathy Nirmalini;Mookerjee Bijoyesh;DeYoung Maurice P.;Kumar Rakesh |
| 分类号 |
A61K38/17;A61K33/24;A61K31/337;G01N33/574;A61K31/519;C07K14/71;C12Q1/68;A61K45/06;A61K31/555 |
主分类号 |
A61K38/17 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of treating cancer having a higher level of FGF2 compared to the level of VEGF in a subject, wherein a higher level of FGF2 compared to the level of VEGF is indicative of therapeutic responsiveness by the cancer to a fibroblast growth factor receptor 1 (FGFR1) extracellular domain (ECD) or an FGFR1 ECD fusion molecule, comprising administering a therapeutically effective amount of an FGFR1 ECD or an FGFR1 ECD fusion molecule to the subject. |
| 地址 |
South San Francisco CA US |
