Methods of treatment using human antibody molecules for IL-13

摘要

Specific binding members, in particular human anti-IL-13 antibody molecules and especially those which neutralise IL-13 activity. Methods for using anti-IL-13 antibody molecules in diagnosis or treatment of IL-13 related disorders, including asthma, atopic dermatitis, allergic rhinitis, fibrosis, inflammatory bowel disease and Hodgkin's lymphoma.

主权项

1. A method of treatment of a disease or disorder selected from the group consisting of asthma, atopic dermatitis, allergic rhinitis, fibrosis and Hodgkin's lymphoma, the method comprising administering a specific binding member to a patient with the disease or disorder, wherein the specific binding member binds interleukin-13 (IL-13) and comprises an antibody antigen-binding site which is composed of a human antibody heavy chain variable region (VH) and a human antibody light chain variable region (VL) comprising a set of complementarity determining regions (CDRs) HCDR1, HCDR2, HCDR3, LCDR1, LCDR2 and LCDR3, wherein the VH comprises HCDR1, HCDR2 and HCDR3 and the VL comprises LCDR1, LCDR2 and LCDR3, wherein:
HCDR1 comprises SEQ ID NO:7; HCDR2 comprises SEQ ID NO:8; HCDR3 comprises SEQ ID NO:9; LCDR1 comprises SEQ ID NO:10; LCDR2 comprises SEQ ID NO:11; and LCDR3 comprises SEQ ID NO:12.