Transdermal therapeutic system for administering the active substance buprenorphine

摘要

The invention relates to a transdermal therapeutic system for administering the active substance buprenorphine. Said system comprises at least one carboxylic acid that determines the solubility of buprenorphine in the matrix layer and that can likewise be absorbed. The transdermal therapeutic system according to the invention is used in the treatment of pain and is characterized by a considerably increased utilization of the active substance.

主权项

1. A transdermal therapeutic system for administering buprenorphine to the skin, comprising:
an active-ingredient-impermeable backing layer; at least one pressure-sensitive adhesive matrix layer comprising the active ingredient buprenorphine and laevulinic acid; wherein the matrix layer comprises a polymer selected from polysiloxanes or polyisobutylene; wherein the buprenorphine is dissolved in the laevulinic acid to form a solution and wherein the solution is dispersed, in the form of droplets, in the matrix layer.